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If you notice these signs, scale back frequency or concentration

In animal models of colitis, TUDCA reduced intestinal inflammation, improved barrier function, and protected gut cells from stress-related injury.26 A recent study in animals and intestinal cells found that TUDCA improved gut barrier integrity and shifted gut bacteria, changes that could reduce inflammation.27 In humans, an open-label pilot trial of 13 patients with active UC found that 6 weeks of TUDCA was safe and associated with improvements in ER stress markers, mucosal healing, and clinical disease activity.37 However, because this study had no placebo group and was very small, larger randomized trials are needed to confirm the benefit

Notably, curcumin ameliorates these behavioral symptoms by restoring redox balance and reducing hippocampal proinflammatory cytokines (Moradi et al., 2023)

doi: 10.1111/his.12721 66 BulunSChengY-HPavoneMXueQAttarETrukhachevaEet al